Artem Plus 30ml Dry Suspension 30/180mg

Requires Prescription: ✅ Yes
Generics: Artemether and Lumefantrine
Used For: Treatment of Malaria
How It Works
 Artemether contains an endoperoxide bridge, which produces free radicals toxic to
malarial parasites.
 Lumefantrine inhibits heme polymerization in parasites, a process crucial for their
survival.
 The combination targets different stages of the parasite lifecycle, ensuring rapid
clearance and lowering recurrence.
Indications
 For the treatment of uncomplicated malaria, especially Plasmodium falciparum.
 Effective where resistance to older antimalarials exists.
Dosage
 Active Ingredients: Artemether + Lumefantrine
 Dosage as prescribed by a healthcare professional (typically 6-dose regimen over 3
days)
 Must be taken with fatty meals to improve absorption.
Side Effects
Very Common:
 Palpitations, headache, dizziness
 Abdominal pain, vomiting, nausea, anorexia
 Arthralgia (joint pain), myalgia (muscle pain), fatigue, asthenia (weakness)
 Sleep disturbances
Common:
 Rash, pruritus (itchiness), diarrhea, insomnia
 Cough, paraesthesia, gait disturbances
 QT interval prolongation on ECG
 Amnesia
Uncommon:
 Elevated liver function tests
 Neurological: clonus, hypoesthesia, ataxia, somnolence
Drug Interactions
Use caution or avoid concurrent use with:
 CYP3A4 inhibitors: erythromycin, ketoconazole, cimetidine, HIV protease inhibitors
 CYP2D6 inhibitors: metoprolol, imipramine, amitriptyline
 Mefloquine – may reduce bioavailability of lumefantrine
When Not to Use
 Known hypersensitivity to Artemether or Lumefantrine
 Avoid in patients with a history of QT prolongation or serious cardiac arrhythmias
Precautions
 Do not co-administer with other antimalarials unless specifically indicated
 Monitor patients with hepatic, renal, or cardiac impairment
 Ensure adequate food intake during treatment to prevent therapeutic failure
Warnings
Warning 1:
Caution in patients with cardiac, renal, or hepatic issues; ECG monitoring is advised.
Warning 2:
Interactions with CYP3A4-modulating drugs can affect drug levels and efficacy.
Warning 3:
Patients who cannot eat during treatment are at higher risk of recurrence due to reduced drug
absorption.
Pregnancy Category
⚠️ Consult a healthcare provider before use during pregnancy or lactation.
Storage
✅ Yes — Store at room temperature, away from heat and direct light