Avasar Tablets 10/160mg

Medicine Name: Avasar Tablets 10/160mg

💊 Avsar Tablets – Product Specification
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📌 Prescription Requirement:
✅ Yes
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🧬 Generics:
Amlodipine Besilate + Valsartan
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🎯 Used For:
Hypertension (high blood pressure)
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⚙️ How It Works:
•    Amlodipine is a calcium channel blocker that relaxes blood vessels to improve blood flow.
•    Valsartan is an angiotensin II receptor blocker (ARB) that prevents blood vessel narrowing.
•    Their combined effect enhances blood pressure control more than either drug alone.
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📋 Usage & Safety
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💊 Dosage:
•    Formulation: Amlodipine Besilate + Valsartan
•    Dose & frequency: As directed by the prescribing physician
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⚠️ Side Effects:
Very Common / Common:
•    Headache, dizziness, fatigue, somnolence
•    Edema (facial, peripheral, pitting), flushing, hot flush
•    Abdominal discomfort, constipation, nausea, diarrhea
•    Back pain, joint pain, rash, dry mouth, visual disturbance
Less Common / Rare:
•    Nasopharyngitis, influenza-like illness
•    Hypokalemia, hyperuricemia, hyperlipidemia
•    Palpitations, tachycardia, orthostatic hypotension
•    Hyponatremia, paraesthesia, vertigo, coordination issues
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🔄 Drug Interactions:
•    CYP3A4 inhibitors: e.g., verapamil, diltiazem, erythromycin
•    CYP3A4 inducers: e.g., rifampicin, St. John’s Wort
•    Grapefruit juice (↑ amlodipine effect)
•    Simvastatin (↑ levels/toxicity risk)
•    Lithium (↑ lithium toxicity risk)
•    NSAIDs (reduced antihypertensive effect, ↑ renal risk)
•    Potassium supplements/diuretics/salt substitutes (↑ hyperkalemia risk)
•    Sildenafil (potential additive hypotensive effects)
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🩺 Indication:
•    Management of essential hypertension, especially where monotherapy is inadequate.
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🚫 When Not to Use:
•    Hypersensitivity to amlodipine, valsartan, or excipients
•    Severe hepatic impairment, biliary cirrhosis, cholestasis
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⚠️ Precautions & Warnings
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⚠️ Precaution:
•    Use with caution in patients with renal artery stenosis or solitary kidney, due to risk of elevated creatinine or urea levels.
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🚨 Warnings:
1.    Hyperkalemia Risk:
Monitor potassium levels closely if used with potassium-affecting drugs or supplements.
2.    Not for Emergency Use:
Not recommended in cases of hypertensive crisis due to lack of established safety.
3.    Risk of Angioedema:
Discontinue immediately if symptoms (e.g., facial or throat swelling) occur. Do not restart.
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🧾 Additional Information
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🤰 Pregnancy Category:
Consult your physician. Avoid during pregnancy unless specifically advised.
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🧊 Storage:
✅ Yes
Store at room temperature, protected from direct light and heat.