Avasar Tablets 5/80mg

Medicine Name: Avasar Tablets 5/80mg
💊 Avsar Tablets – Product Specification
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📌 Requires Prescription:
✅ Yes
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🧬 Generics (Active Ingredients):
•    Amlodipine Besilate
•    Valsartan
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🎯 Used For:
•    Hypertension (High Blood Pressure)
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⚙️ How It Works:
•    Amlodipine is a calcium channel blocker (dihydropyridine class) that relaxes vascular smooth muscle, causing vasodilation and lowering blood pressure.
•    Valsartan is an angiotensin II receptor blocker (ARB) that prevents vasoconstriction and aldosterone secretion, contributing to further blood pressure reduction.
•    Together, they provide synergistic blood pressure control.
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📋 Usage & Safety
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💊 Dosage:
•    Generic Composition: Amlodipine Besilate + Valsartan
•    Common Dosages: 5/80 mg, 5/160 mg, 10/160 mg (consult physician for appropriate strength)
•    Route: Oral
•    Frequency: Once daily or as prescribed by the physician
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⚠️ Side Effects:
Common:
•    Headache, dizziness, fatigue
•    Edema (peripheral or pitting), facial flushing
•    Nasopharyngitis, influenza-like symptoms
•    Hypokalemia, hyperuricemia
•    Abdominal discomfort, nausea, diarrhea
•    Back pain, joint swelling, arthralgia
Less Common/Rare:
•    Visual impairment, paraesthesia, somnolence
•    Palpitations, tachycardia, orthostatic hypotension
•    Rash, erythema
•    Cough, pharyngolaryngeal pain
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🔄 Drug Interactions:
•    Antihypertensives (additive hypotensive effect)
•    Grapefruit juice (increases amlodipine levels)
•    CYP3A4 inhibitors: erythromycin, ketoconazole, verapamil (↑ amlodipine effect)
•    CYP3A4 inducers: rifampicin, St. John’s Wort (↓ amlodipine effect)
•    NSAIDs (reduced renal function and antihypertensive effect)
•    Lithium (↑ risk of lithium toxicity)
•    Potassium supplements or sparing diuretics (↑ risk of hyperkalemia)
•    Simvastatin (↑ simvastatin concentration)
•    Sildenafil (additive BP-lowering effect)
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🩺 Indication:
•    For the treatment of essential hypertension in patients whose blood pressure is not adequately controlled by either agent alone or in those who require combination therapy.
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🚫 When Not to Use:
Do not use if:
•    Hypersensitive to amlodipine, valsartan, dihydropyridines, or excipients
•    Have severe hepatic impairment, biliary cirrhosis, or cholestasis
•    Have experienced angioedema with ARBs
•    During pregnancy or breastfeeding (unless approved by physician)
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⚠️ Precautions & Warnings
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🟡 Precaution:
•    Use with caution in renal artery stenosis or solitary kidney — monitor urea and creatinine.
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🚨 Warnings:
1. Hyperkalemia Risk:
•    Use caution with potassium-rich diets, potassium-sparing diuretics, or supplements. Monitor serum potassium levels regularly.
2. Not for Hypertensive Crisis:
•    Amlodipine + Valsartan is not suitable for hypertensive emergencies.
3. Angioedema Warning:
•    Rare but serious: discontinue immediately if facial, tongue, or throat swelling occurs. Do not reinitiate treatment.
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📎 Additional Information
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🤰 Pregnancy Category:
•    Contraindicated in pregnancy. Use only under medical supervision. Always consult a healthcare provider before use.
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🧊 Storage:
✅ Yes
•    Store at room temperature, protected from direct sunlight and moisture.