Avodart Capsules 0.5mg

 Medicine Name: Avodart Capsules 0.5mg
Avodart Capsules Specification
 Requires Prescription: Yes
 Generic Name: Dutasteride
 Used For: Benign Prostatic Hyperplasia (BPH)
How It Works
Dutasteride inhibits the conversion of testosterone to dihydrotestosterone (DHT), a hormone
responsible for prostate growth. It blocks both type 1 and type 2 5α-reductase isoenzymes,
forming a stable complex with slow dissociation. Dutasteride does not bind to androgen
receptors.
Usage and Safety
 Typical Dosage: As prescribed; contains Dutasteride.
 Common Side Effects:
o Skin rash or hives
o Swelling (face, limbs, eyelids, lips)
o Erectile dysfunction (may persist after discontinuation)
o Decreased libido and ejaculate volume
o Breast enlargement or tenderness (gynecomastia)
o Dizziness (especially with tamsulosin)
o Hair loss or unusual hair growth
o Rare: Heart failure
 Drug Interactions:
o Calcium channel blockers (e.g., Verapamil, Diltiazem)
o Antivirals (e.g., Ritonavir, Indinavir)
o Antifungals (e.g., Itraconazole, Ketoconazole)
o Nefazodone (antidepressant)
o Alpha-blockers (e.g., for high blood pressure or BPH)
Indications
 Treats Benign Prostatic Hyperplasia (BPH) in men
 Reduces the size of an enlarged prostate by lowering DHT levels
Contraindications (When Not to Use)
 Allergy to Dutasteride, other 5-alpha reductase inhibitors, soya, or peanuts
 Severe liver disease
Precautions
 Rule out prostate cancer or other urological diseases before starting treatment
 Monitor patients with high residual urine volume or poor urinary flow
Warnings
1. Skin Absorption Risk: Dutasteride can be absorbed through skin—avoid contact if
capsule leaks. Wash immediately if exposure occurs.
2. Blood Donation: Avoid donating blood for 6 months after stopping treatment to
prevent transmission to pregnant women.
3. Drug Combination Risk: Combining with PDE5 inhibitors or alpha-blockers may
cause hypotension (low blood pressure).
Additional Information
 Pregnancy Category: Not for use by women; consult physician before use.
 Storage: Yes — Store at room temperature, away from light and heat.