Medicine Name: Avsar Plus Tablets 160/10/12.5mg
💊 Avsar Plus Tablets – Specification
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📄 Requires Prescription:
✅ Yes
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🧪 Generics (Active Ingredients):
• Valsartan
• Amlodipine
• Hydrochlorothiazide
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🎯 Used For:
Management of Essential Hypertension in adults
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⚙️ How It Works:
• Valsartan (ARB): Blocks angiotensin II, reducing vasoconstriction and aldosterone-related sodium/water retention.
• Amlodipine (Calcium Channel Blocker): Inhibits calcium influx into vascular smooth muscle and myocardium, leading to vasodilation.
• Hydrochlorothiazide (Thiazide Diuretic): Inhibits Na⁺/Cl⁻ reabsorption in the kidneys, promoting diuresis and lowering blood volume.
Combined, these agents reduce blood pressure via complementary mechanisms.
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📋 Usage and Safety
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💊 Dosage:
As prescribed by a physician. Based on clinical evaluation of blood pressure, kidney function, and patient response.
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⚠️ Side Effects:
Hematologic:
• Agranulocytosis, aplastic anemia, leukopenia, neutropenia, thrombocytopenia
Metabolic:
• Hyperuricemia, hyperglycemia, hypokalemia, hypomagnesemia, hypercalcemia, hypochloremic alkalosis
Neurological:
• Headache, visual disturbances, hypertonia
Cardiac:
• Bradycardia, ventricular tachycardia, atrial fibrillation (arrhythmias)
Others:
• Anorexia, bone marrow suppression
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🔄 Drug Interactions:
• Amlodipine:
CYP3A4 inhibitors (e.g. ketoconazole, erythromycin), CYP3A4 inducers (rifampicin, phenytoin), grapefruit juice, simvastatin, sildenafil, dantrolene, immunosuppressants
• Valsartan:
Potassium-sparing diuretics, potassium supplements, NSAIDs (including COX-2 inhibitors), lithium, rifampicin, cyclosporine, ritonavir
• Hydrochlorothiazide:
Lithium, metformin, antidepressants, antipsychotics, antiepileptics (e.g., carbamazepine), cholestyramine, digitalis glycosides, alcohol, barbiturates, cytotoxic agents
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📌 Indication:
For the treatment of essential hypertension where combination therapy is appropriate.
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🚫 When Not to Use:
• Known hypersensitivity to valsartan, amlodipine, hydrochlorothiazide, or related substances (sulphonamides/dihydropyridines)
• Pregnancy (2nd and 3rd trimester)
• Severe hepatic impairment, biliary cirrhosis, or cholestasis
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⚠️ Precautions and Warnings
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⚠️ Precaution:
Use with caution in patients with:
• Unilateral/bilateral renal artery stenosis
• Single kidney (risk of increased blood urea and serum creatinine)
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⚠️ Warnings:
1. Pregnancy Risk:
Drugs affecting the renin-angiotensin system during 2nd/3rd trimesters may cause fetal injury or death (renal dysfunction, oligohydramnios, skeletal issues).
2. Volume/Salt Depletion:
Symptomatic hypotension may occur in patients with reduced intravascular volume (e.g. high-dose diuretic use).
3. Renal Impairment:
Can lead to acute renal failure, especially in patients with compromised renal function or under diuretic therapy.
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🧾 Additional Information
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🤰 Pregnancy Category:
Avoid during pregnancy. Always consult your physician before use.
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📦 Storage Required:
✅ Yes – Store at room temperature, protected from direct light and heat.
