Avsar Plus 10/160/25mg

Medicine Name: Avsar Plus Tablet 160/10/25mg
💊 Avsar Plus Tablets – Product Specification
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✅ Requires Prescription
Yes
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🧪 Generics
•    Valsartan (ARB – Angiotensin II Receptor Blocker)
•    Amlodipine (Calcium Channel Blocker)
•    Hydrochlorothiazide (Thiazide Diuretic)
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🩺 Used For
Treatment of Essential Hypertension in adults
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⚙️ How It Works
•    Valsartan: Blocks angiotensin II effects, reducing vasoconstriction and aldosterone release, leading to lower blood pressure.
•    Amlodipine: Relaxes vascular smooth muscle by inhibiting calcium influx, resulting in vasodilation and reduced blood pressure.
•    Hydrochlorothiazide: Inhibits Na⁺/Cl⁻ symporter in kidneys, promoting sodium and water excretion, reducing blood volume and pressure.
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📋 Usage and Safety
💊 Dosage
Combination: Valsartan + Amlodipine + Hydrochlorothiazide
Exact strength and frequency to be determined by a healthcare provider.
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⚠️ Side Effects
•    Hematologic: Agranulocytosis, bone marrow suppression, aplastic anemia, leukopenia, thrombocytopenia
•    Metabolic: Hypokalemia, hypomagnesemia, hypercalcemia, hyperglycemia, hyperuricemia, hyperlipidemia
•    Neurological/Cardiac: Headache, hypertonia, arrhythmias (bradycardia, tachycardia, AFib), visual disturbances
•    GI/Other: Anorexia, hemolytic anemia, electrolyte imbalances, hypochloremic alkalosis
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🔄 Drug Interactions
•    Amlodipine:
o    CYP3A4 inhibitors (e.g. ketoconazole, ritonavir)
o    CYP3A4 inducers (e.g. carbamazepine, rifampicin)
o    Simvastatin, Sildenafil, grapefruit juice, immunosuppressants
•    Valsartan:
o    Potassium-sparing diuretics, potassium supplements
o    NSAIDs (including COX-2 inhibitors), lithium, rifampicin, cyclosporine, ritonavir
•    Hydrochlorothiazide:
o    Antidiabetics (e.g. metformin), antidepressants
o    Cholestyramine, digitalis glycosides, cytotoxic agents
o    Alcohol, barbiturates, methyldopa, lithium
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🚫 When Not to Use
•    Known hypersensitivity to valsartan, amlodipine, hydrochlorothiazide, or sulfonamide/dihydropyridine derivatives
•    Pregnancy (2nd & 3rd trimesters)
•    Severe hepatic impairment, biliary cirrhosis, or cholestasis
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⚠️ Precautions & Warnings
⚠️ Precaution
Use with caution in renal artery stenosis or solitary kidney due to risk of elevated serum creatinine and blood urea nitrogen.
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⚠️ Warnings
1.    Fetal Risk:
Use of renin-angiotensin inhibitors during pregnancy can lead to fetal injury/death (oligohydramnios, renal dysfunction, skeletal deformities).
2.    Hypotension Risk:
Patients with volume/salt depletion (e.g., due to diuretics) may experience symptomatic hypotension.
3.    Renal Function:
Use may result in acute renal failure, particularly in those with compromised kidney function or on concurrent nephrotoxic agents.
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📎 Additional Information
•    Pregnancy Category:
⚠️ Not safe during pregnancy – consult your physician
•    Storage:
✅ Store at room temperature, protected from direct light and heat