Medicine Name: Avsar Plus Tablets 160mg/5mg/12.5mg
💊 Avsar Plus Tablets – Product Specification
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📌 Requires Prescription:
✅ Yes
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🧬 Generics:
Valsartan + Amlodipine + Hydrochlorothiazide
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🎯 Used For:
Treatment of essential hypertension (high blood pressure) in adults
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⚙️ How It Works:
• Valsartan: An angiotensin II receptor blocker (ARB) that reduces vasoconstriction and aldosterone secretion, lowering blood pressure.
• Amlodipine: A calcium channel blocker that inhibits calcium ion influx into vascular smooth muscle and cardiac muscle, causing vasodilation.
• Hydrochlorothiazide (HCT): A thiazide diuretic that promotes sodium and chloride excretion, decreasing plasma volume and blood pressure.
These agents act synergistically to control blood pressure more effectively than individual therapy.
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📋 Usage & Safety
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💊 Dosage:
Valsartan + Amlodipine + Hydrochlorothiazide
→ Dosage as directed by a physician, based on patient condition and response.
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⚠️ Side Effects:
Blood & Metabolic:
• Agranulocytosis, bone marrow failure, aplastic anemia
• Hemolytic anemia, leukopenia, neutropenia, thrombocytopenia
• Hypokalemia, hypomagnesemia, hyperuricemia, hyperglycemia, hypercalcemia
Neurological:
• Headache, hypertonia, visual disturbances
Cardiovascular:
• Arrhythmias (bradycardia, ventricular tachycardia, atrial fibrillation)
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🔄 Drug Interactions:
Amlodipine:
• CYP3A4 inhibitors: ketoconazole, itraconazole, erythromycin, clarithromycin
• CYP3A4 inducers: carbamazepine, phenytoin, rifampicin
• Sildenafil, simvastatin, grapefruit juice
• Immunosuppressants, dantrolene
Valsartan:
• Potassium-sparing diuretics, potassium supplements, NSAIDs, lithium, rifampicin
Hydrochlorothiazide:
• Lithium, metformin, cholestyramine, colestipol
• Beta-blockers, digitalis glycosides, cytotoxic agents, methyldopa
• Alcohol, barbiturates, narcotics
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🩺 Indication:
Used for management of essential hypertension in adults when combination therapy is appropriate.
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🚫 When Not to Use:
• Hypersensitivity to any of the active ingredients or related compounds (sulphonamides, dihydropyridines)
• Pregnancy (especially second and third trimesters)
• Severe hepatic impairment, biliary cirrhosis, or cholestasis
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⚠️ Precautions & Warnings
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⚠️ Precaution:
Use with caution in patients with renal artery stenosis, especially those with a single functioning kidney — risk of raised creatinine/urea.
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🚨 Warnings:
1. Pregnancy Risk (Black Box Warning):
Use of renin-angiotensin inhibitors during 2nd/3rd trimester can harm the fetus (renal failure, lung hypoplasia, skeletal deformities).
2. Volume Depletion:
In salt- or volume-depleted patients, symptomatic hypotension may occur — correct condition before initiating therapy or monitor closely.
3. Renal Function Impairment:
Can cause or worsen renal dysfunction including acute renal failure, especially with diuretics or in patients with underlying renal disease.
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🧾 Additional Information
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🤰 Pregnancy Category:
Consult your physician. Contraindicated in 2nd and 3rd trimester.
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🧊 Storage Required:
✅ Yes
Store at room temperature, away from direct light and heat.
