Medicine Name: Avsar Plus Tablets 160/5/25mg
💊 Avsar Plus Tablets – Product Specification
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✅ Requires Prescription
Yes
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🧪 Generic Components
• Valsartan (ARB)
• Amlodipine (Calcium Channel Blocker)
• Hydrochlorothiazide (Thiazide Diuretic)
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🩺 Used For
Treatment of Essential Hypertension in adults
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⚙️ How It Works
• Valsartan: Blocks angiotensin II, preventing vasoconstriction and aldosterone release, thereby lowering blood pressure.
• Amlodipine: Inhibits calcium entry into vascular smooth muscle, causing vasodilation and lowering blood pressure.
• Hydrochlorothiazide: Inhibits Na⁺/Cl⁻ reabsorption in kidneys, increasing diuresis, reducing blood volume and blood pressure.
These agents work synergistically to provide enhanced blood pressure control.
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📋 Usage and Safety
💊 Dosage
Based on individual patient needs and physician evaluation. Follow the doctor’s prescription strictly.
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⚠️ Side Effects
• Hematological:
Agranulocytosis, bone marrow suppression, hemolytic anemia, leukopenia, neutropenia, thrombocytopenia, aplastic anemia
• Metabolic/Electrolyte:
Hypercalcemia, hyperglycemia, hyperlipidemia, hyperuricemia, hypokalemia, hypomagnesemia, hypochloremic alkalosis
• Neurological & Cardiac:
Headache, visual disturbances, hypertonia, arrhythmias (e.g., bradycardia, ventricular tachycardia, atrial fibrillation)
• Others:
Anorexia
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🔄 Drug Interactions
• Amlodipine:
o CYP3A4 inhibitors (e.g. ketoconazole, erythromycin)
o CYP3A4 inducers (e.g. rifampicin, phenytoin)
o Grapefruit juice, simvastatin, sildenafil
o Immunosuppressants, dantrolene
• Valsartan:
o Potassium-sparing diuretics (e.g. spironolactone)
o Heparin, lithium, NSAIDs
o Rifampicin, cyclosporin, ritonavir
• Hydrochlorothiazide:
o Antidiabetics (e.g. metformin), antidepressants, antiepileptics
o Cholestyramine, lithium, digitalis glycosides
o Alcohol, barbiturates, cytotoxic agents
o Methyldopa, iodine contrast, tubocurarine
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🚫 Contraindications (When Not to Use)
• Hypersensitivity to any active ingredient or related drug class (e.g., sulphonamides, dihydropyridines)
• Pregnancy (especially 2nd and 3rd trimesters)
• Severe hepatic impairment, biliary cirrhosis, or cholestasis
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⚠️ Precautions & Warnings
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⚠️ Precaution
• Use caution in patients with renal artery stenosis (unilateral/bilateral) or single kidney—may cause increased serum creatinine and urea.
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⚠️ Warnings
1. Pregnancy Risk:
Drugs acting on the renin-angiotensin system can cause fetal injury or death in 2nd/3rd trimesters (e.g., renal dysfunction, skeletal deformities).
2. Volume/Salt Depletion:
Symptomatic hypotension can occur in patients on high-dose diuretics. Stabilize before starting treatment.
3. Renal Risk:
Risk of acute renal failure due to the combined effects of valsartan and diuretics.
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📎 Additional Information
• Pregnancy Category:
Not recommended during pregnancy—consult your physician before use.
• Storage:
✅ Yes – Store at room temperature, protected from light and heat.
