PANADOL

: Description

Panadol Tablets Specification

• Requires Prescription: No
• Generic Name: Paracetamol
• Used For: Pain & Fever

Mechanism of Action

Paracetamol acts centrally to relieve pain, primarily through activation of descending serotonergic pathways. There is ongoing debate about its exact mechanism, which may involve:

• Inhibition of prostaglandin synthesis, or
• Influence of an active metabolite on cannabinoid receptors.

Usage and Safety

Dosage

Active ingredient: Paracetamol (dosage to be as per label or physician’s recommendation)

Side Effects

• Thrombocytopenia
• Anaphylaxis
• Cutaneous hypersensitivity reactions:
• Skin rashes
• Angioedema
• Stevens-Johnson Syndrome (SJS)
• Toxic Epidermal Necrolysis (TEN)
• Bronchospasm (especially in aspirin/NSAID-sensitive individuals)
• Hepatic dysfunction

Drug Interactions

• May enhance the anticoagulant effect of warfarin and other coumarins with prolonged regular use

Occasional doses usually have no significant effect