Tiovair Rota Capsules 18mcg

Medicine Name: Tiovair Rota Capsules 18mcg
Tiovair Rotacaps – Product Specification
Requires Prescription:
Yes
Generic Name:
Tiotropium Bromide
Used For:
Chronic Obstructive Pulmonary Disease (COPD) – including chronic bronchitis and
emphysema
How It Works:
Tiotropium is a long-acting antimuscarinic (anticholinergic) agent that binds to muscarinic
receptors (M1 to M5) in the airway smooth muscles. Its primary therapeutic action occurs
through M3 receptor inhibition, which leads to sustained bronchodilation. The
bronchodilatory effect lasts over 24 hours due to slow dissociation from M3 receptors,
providing long-term symptom relief in COPD patients.
Dosage:
Contains Tiotropium Bromide
Dosage to be administered as prescribed by the physician.
Side Effects:
 Common:
o Dry mouth
 Uncommon:
o Dizziness, headache, altered taste, blurred vision, cough, pharyngitis, dysphonia,
gastroesophageal reflux, constipation, oral thrush, urinary retention
 Rare:
o Insomnia, glaucoma, increased intraocular pressure, arrhythmias, epistaxis,
bronchospasm, nausea, rash, hypersensitivity, angioedema, UTI
 Not Known:
o Dehydration, dental caries, skin ulcers, joint swelling, anaphylaxis
Drug Interactions:
 Safe with:
o Short-acting and long-acting β2-agonists, methylxanthines, corticosteroids
 Caution with:
o Other anticholinergic drugs — avoid co-administration due to risk of increased
anticholinergic adverse effects
Indications:
Tiotropium is indicated for:
 Long-term, once-daily maintenance of bronchospasm in COPD
 Prevention of exacerbations in COPD patients
When Not to Use:
 Contraindicated in:
o Patients with known hypersensitivity to:
 Tiotropium
 Atropine or its derivatives (e.g., ipratropium, oxitropium)
 Any excipients in the formulation
Precautions:
 Not to be used for acute bronchospasm
 Intended for maintenance therapy only, not for emergency relief
Warnings:
1. May cause severe allergic reactions (e.g., urticaria, angioedema, bronchospasm). Discontinue
immediately if such reactions occur.
2. Paradoxical bronchospasm can occur. If so, treat with a short-acting beta2-agonist and stop
tiotropium.
3. Use with caution in patients with renal impairment (CrCl < 60 mL/min); monitor for
anticholinergic side effects.
Pregnancy Category:
Always consult your healthcare provider before use during pregnancy or breastfeeding.
Storage:
Yes – Store at room temperature, away from direct light and heat.